ПУБЛИКАЦИИ ПО BSD‑500 И BSD‑2000
КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ ПО ГИПЕРТЕРМИИ

В представленной ниже таблице приведены результаты клинических исследований по гипертермии, проведённых за последние 30 лет, подтверждающих эффективность применения локальной и регионарной гипертермии в качестве дополнительного метода лечения с лучевой терапией и/или химиотерапией.

Year Tumor Author Title No. of Patients Method System Journal Abstract
2019 Breast Cancer De-Colle Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study (2019) 20 RT+HT BSD‑500 Strahlenther Onkol Read Abstract
2018 Soft Tissue Sarcoma Issels Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma. The EORTC 62961-ESHO 95 Randomized Clinical Trial (2018) 341 CT vs.
CT+HT
BSD‑2000 JAMA Oncol Read Abstract
2018 Rectal Cancer Zwirner External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia (2018) 86 RCT+HT BSD‑2000 IJH Read Abstract
2014 Soft Tissue Sarcoma Angele Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. (2014) 341 CT vs.
CT+HT
BSD‑2000 Ann Surg Oncol Read Abstract
2013 Pancreatic Cancer Tschoep-Lechner Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer. (2013) 23 CT+HT BSD‑2000 IJH Read Abstract
2012 Cervical Cancer Westermann Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update. (2012) 68 RT+HT BSD‑2000 IJH Read Abstract
2012 Rectal Cancer Schroeder Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. (2012) 106 RCT vs.
RCT+HT
BSD‑2000 IJH Read Abstract
2012 Cervical Cancer Heijkoop Neoadjuvant chemotherapy followed by radiotherapy and concurrent hyperthermia in patients with advanced-stage cervical cancer: a retrospective study (2012) 43 RCT+HT BSD‑2000 IJH Read Abstract
2014 Cervical Cancer Heijkoop Results of concurrent chemotherapy and hyperthermia in patients with recurrent cervical cancer after previous chemoradiation (2014) 38 Re-CT+HT BSD‑2000 IJH Read Abstract
2011 Pancreatic Cancer Maluta Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer : an open-label comparative cohort trial (2011) 68 RCT+HT BSD‑2000 Strahlenther Onkol Read Abstract
2010 Ovarian Cancer Fotopoulou Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study (2010) 36 CT+HT BSD‑2000 IJH Read Abstract
2010 Soft Tissue Sarcoma Issels Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. (2010) 341 CT vs.
CT+HT
BSD‑2000 Lancet Read Abstract
2010 Rectal Cancer Maluta Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum (2010) 76 RCT+HT BSD‑2000 IJH Read Abstract
2010 Soft Tissue Sarcoma Schlemmer Thermochemotherapy in patients with extremity high-risk soft tissue sarcomas (HR-STS) (2010) 47 RCT+HT BSD‑2000 IJH Read Abstract
2009 Bladder Cancer Wittlinger Quadrimodal treatment of high-risk T1 and T2 bladder cancer: transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia (2009) 45 RCT+HT BSD‑2000 Radiother Oncol Read Abstract
2009 Cervical Cancer Franckena Radiotherapy and hyperthermia for treatment of primary locally advanced cervix cancer: results in 378 patients (2009) 378 RT+HT BSD‑2000 IJROBP Read Abstract
2008 Rectal Cancer Milani Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer (2008) 24 RCT+RHT BSD‑2000 Strahlenther Onkol Read Abstract
2008 Cervical Cancer Franckena Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial. (2008) 114 RT vs.
RT+HT
BSD‑2000 IJROBP Read Abstract
2007 Prostate Cancer Maluta Conformal radiotherapy plus local hyperthermia in patients affected by locally advanced high risk prostate cancer: preliminary results of a prospective phase II study (2007) 144 CRT+HT BSD‑2000 IJH Read Abstract
2007 Vaginal Cancer Aktas Concomitant radiotherapy and hyperthermia for primary carcinoma of the vagina: a cohort study. (2007) 44 RT+HT BSD‑2000 Eur J Obstet Read Abstract
2006 Cervical Cancer Sreenivasa Radiochemotherapy combined with regional pelvic hyperthermia induces high response and resectability rates in patients with nonresectable cervical cancer > or =FIGO IIB "bulky". (2006) 32 RCT+HT BSD‑2000 IJROBP Read Abstract
2006 Ovarian Cancer Jones Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma (2006) 41 CT+HT BSD‑2000 IJH Read Abstract
2005 Cervical Cancer Westermann First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma. (2005) 68 RCT+HT BSD‑2000 Cancer Read Abstract
2005 Ovarian Cancer Hahn Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin. (2005) 32 CT+HT BSD‑2000 IJH Read Abstract
2005 Ovarian Cancer Alvarez Secord Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer. (2005) 30 CT+HT BSD‑2000 IJH Read Abstract
2005 Prostate Cancer Tilly Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0. (2005) 22 RT+HT BSD‑2000 Strahlenther Onkol Read Abstract
2004 Rectal Cancer Hildebrandt Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. (2004) 9 RT+HT BSD‑2000 IJH Read Abstract
2004 Soft Tissue Sarcoma Fiegl Ifosfamide, carboplatin and etoposide (ICE) as second-line regimen alone and in combination with regional hyperthermia is active in chemo-pre-treated advanced soft tissue sarcoma of adults. (2004) 20 CT+HT BSD‑2000 IJH Read Abstract
2003 Rectal Cancer Juffermans Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. (2003) 54 RT+HT BSD‑2000 Cancer Read Abstract
2003 Cervical Cancer Jones A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma. (2003) 12 RT+HT BSD‑2000 Cancer Read Abstract
2003 Prostate Cancer Kalapurakal Efficacy of irradiation and external hyperthermia in locally advanced, hormone-refractory or radiation recurrent prostate cancer: a preliminary report. (2003) 13 RT+HT BSD‑2000 IJROBP Read Abstract
2003 Cervical Cancer Van der Zee The Dutch Deep Hyperthermia Trial: results in cervical cancer (2003) 114 RT vs.
RT+HT
BSD‑2000 IJH Read Abstract
2003 Pediatric Tumors Wessalowski An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors (2003) 39 CT+HT BSD‑2000 Klin Padiatr Read Abstract
2013 Germ Cell Tumors Wessalowski Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study (2013) 44 CT+HT BSD‑2000 Lancet Oncol Read Abstract
2002 Soft Tissue Sarcoma Wendtner Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas. (2002) 58 CT+HT BSD‑2000 JCO Read Abstract
2001 Soft Tissue Sarcoma Issels Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study. (2001) 59 CT+HT BSD‑2000 Eur J Cancer Read Abstract
2001 Germ Cell Tumors Schneider Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. (2001) 22 CT+HT BSD‑2000 JCO Read Abstract
2001 Soft Tissue Sarcoma Wendtner Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia. (2001) 54 RCT+HT BSD‑2000 Eur J Cancer Read Abstract
2001 Prostate Cancer Kalapurakal Re-irradiation and external hyperthermia in locally advanced, radiation recurrent, hormone refractory prostate cancer: a preliminary report. (2001) 3 RT+HT BSD‑2000 Br J Radiol Read Abstract
2000 Rectal Cancer Anscher A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. (2000) 15 CT+HT BSD‑2000 IJROBP Read Abstract
2000 Cervical Cancer Van der Zee Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group (2000) 114 RT vs.
RT+HT
BSD‑2000 Lancet Read Abstract
2000 Rectal Cancer Rau Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. (2000) 55 RCT+HT BSD‑2000 IJROBP Read Abstract
2000 Bladder Cancer Van der Zee Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group (2000) 101 CT+RT vs.
RT+HT
BSD‑2000 Lancet Read Abstract
2000 Rectal Cancer Van der Zee Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group (2000) 143 RT vs.
RT+HT
BSD‑2000 Lancet Read Abstract
1999 Soft Tissue Sarcoma Prosnitz The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. (1999) 97 RT+HT BSD‑2000 IJROBP Read Abstract
1999 Cervical Cancer de Wit A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix. (1999) 19 CT+HT BSD‑2000 Br J Radiol Read Abstract
1998 Germ Cell Tumors Wessalowski Hyperthermia for the treatment of patients with malignant germ cell tumors: a phase I/II study in ten children and adolescents with recurrent or refractory tumors (1998) 7 CT+HT BSD‑2000 Cancer Read Abstract
1998 Rectal Cancer Rau Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial. (1998) 37 RCT+HT BSD‑2000 Ann Surg Oncol Read Abstract
1997 Germ Cell Tumors Wessalowski Treatment results in children and adolescents with loco-regional recurrences of abdominal germ cell tumors (GCTs): a pilot-study with PEI chemotherapy and regional deep hyperthermia (RHT) in comparison to a matched cohort (1997) 9 CT+HT BSD‑2000 Klin Padiatr Read Abstract
1997 Prostate Cancer Anscher Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate. (1997) 30 RT+HT BSD‑2000 IJROBP Read Abstract
1996 Deep Tumors Myerson A phase I/II study to evaluate radiation therapy and hyperthermia for deep-seated tumours: a report of RTOG 89-08. (1996) 66 RT+HT BSD‑2000 IJH Read Abstract
1994 Soft Tissue Sarcoma Scully Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas (1994) 40 RT+HT BSD‑2000 J Surg Oncol Read Abstract
1994 Head & Neck Tumor Valdagni Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes: a prospective randomized clinical trial. (1994) 44 RT vs.
RT+LHT
BSD‑500 IJROBP Read Abstract
1991 Prostate Cancer Kaplan Secondary external-beam radiotherapy and hyperthermia for local recurrence after 125-iodine implantation in adenocarcinoma of the prostate (1991) 6 RT+HT BSD‑2000 IJROBP Read Abstract
1991 Genitourinary Cancer Petrovich Regional hyperthermia in patients with recurrent genitourinary cancer. (1991) 53 RT vs.
RT+HT
BSD‑2000 Am J Clin Oncol Read Abstract
1990 Soft Tissue Sarcoma Issels Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study. (1990) 40 CT+HT BSD‑2000 JCO Read Abstract
2019 Rectal Cancer Ott Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus (2019) 112 RCT vs
RCT + HT
BSD‑2000 Strahlenther Onkol Read Abstract
2016 Breast Cancer Auoragh Re-irradiation of the chest wall for local breast cancer recurrence : Results of salvage brachytherapy with hyperthermia. (2016) 18 Re-RT + IHT BSD‑500 Strahlenther Onkol Read Abstract
2002 Head & Neck Tumor Geiger Pulsed-dose rate brachytherapy with concomitant chemotherapy and interstitial hyperthermia in patients with recurrent head-and-neck cancer. (2002) 15 Re-RT +
CT+IHT
BSD‑500 Brachytherapy Read Abstract
2000 Soft Tissue Sarcoma Zschaeck Neoadjuvant chemotherapy plus radiation versus chemotherapy plus regional hyperthermia in high-grade soft tissue sarcomas: a retrospective comparison. (2000) 61 CT+RT vs.
CT+HT
BSD‑2000 Brachytherapy Read Abstract
2019 Cervical Cancer Datta Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials (2019) 9894 Various IJROBP Read Abstract
2016 Breast Cancer (recurrent) Datta Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis. (2016) 627 Various IJROBP Read Abstract
2016 Head & Neck Tumor Datta Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis. (2016) 451 Various IJH Read Abstract
2017 Cervical Cancer Datta Concurrent chemoradiotherapy vs. radiotherapy alone in locally advanced cervix cancer: A systematic review and meta-analysis. (2017) 2445 Various Gynecol Oncol Read Abstract
2016 Cervical Cancer Datta Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: a systematic review with conventional and network meta-analyses. (2016) 807 Various IJH Read Abstract
2015 Summary Review Cihoric Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. (2015) Various IJH Read Abstract
2013 Summary Review Overgaard The heat is (still) on--the past and future of hyperthermic radiation oncology. (2013) Various Radiother Oncol Read Abstract
2002 Summary Review Wust Hyperthermia in combined treatment of cancer. (2002) Various IJH Read Abstract
2016 Summary Review Issels Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application. (2016) Various IJH Read Abstract
CHT
Chemothyperthermia
HT
Hyperthermia
IHT
Interstitial Hyperthermia
LHT
Local Hyperthermia
RCT
RadioChemotherapy
RT
Radiotherapy