The results of a multi-centric clinical Phase III study that included 306 patients with superficial localized breast carcinoma were published in 1996 by Vernon, Hand, Field, et.al (London, Great Britain) in the International Journal of Radiation Oncology, Biology, Physics. The results showed that the rate of complete remission increased from 41% to 59%, and the recurrence-free survival rate from 30% to 50%, when comparing the combined hyperthermia and radiation therapy treatment with radiation therapy alone (refer to vol. 35, no. 4, pp. 731-744).